The effect of prognostic factors and potential treatment regimens on fatality COVID-19 patients

The ongoing outbreak of the Coronavirus disease 2019 (COVID-19) as named by the World Health Organization has millions of confirmed cases worldwide and has claimed hundreds of thousands of lives. The virus was named SARS-CoV-2 in February by the International Committee on Taxonomy of Viruses. COVID-19 presents as fever dry cough dyspnea headache and pneumonia. In a small subset of severe cases the disease quickly progresses to respiratory failure and even death. This study aimed to know the effects of clinical and laboratory features on investigated death. The diagnosis was based on typical findings in thoracic computed tomography (CT) and positive results of the Real-Time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) SARS-CoV-2. The demographic characteristics of COVID-19 patients treated accompanying comorbid conditions and laboratory criteria (blood lymphocyte counts C Reactive Protein (CRP) D-dimer Interleukin 6 (IL-6) blood neutrophil count/lymphocyte counts) were collected retrospectively. The results show that 121 cases 66 (54.54%) were male 55 (45.46%) were female and the mean age was ± Std (Min-Max) 59.63 ± 17.4 (22-91). Neutrophil percentage (p = 0.027) neutrophil / lymphocyte ratio (NE / LE) (p = 0.028) CRP (p = <0.001) PCT (p = 0.004) D dimer (p = 0.021) and IL 6 (p = 0.047) in patients with a fatal course higher values were found than those recovered. Blood lymphocyte count (p = 0.001) and percent (p <0.001) were lower. Number of blood white spheres (p = 0.010) blood neutrophil counts (p = 0.001) and percentage (p <0.001) NE / LE (p0.001) CRP (p <0.001) PCT (p = 0.003) and IL -6 (p <0.001) levels were higher in patients with severe clinical findings than in mild cases. The case death rate was observed as 9%. COVID-19 patients should consider blood neutrophil percentage blood lymphocyte count blood lymphocyte percentage NE / LE CRP D dimer and IL 6 values as an early warning in terms of prognosis. More experience was needed to assess the benefits of immune plasma tocilizumab IVIG treatments and remdesivir therapy recently introduced to the treatment protocol.

The relationship between severe acute respiratory syndrome coronavirus 2 (SARS - COV - 2) pandemic and fragmented QRS.

OBJECTIVE: The aim of the study is to determine the frequency of fragmented QRS (FQRS) in patients with SARS - COV - 2. METHODS: A total of 125 consecutive patients over 20 years of age who were hospitalized for SARS - COV - 2 between 20th March 2020 and 18th May 2020 were included in the study. The data of the patients in the inpatient ward and in the intensive care unit were recorded separately. The duration of QRS and presence of FQRS were evaluated by two experienced cardiologists. The patients were divided into two groups as FQRS positive and FQRS negative considering presence of FQRS. Moreover, the frequency of FQRS in the patients in the inpatient ward and in the intensive care unit were compared with each other. RESULTS: FQRS was found in 24% of the patients who had SARS-COV-2. There was no difference between FQRS positive and negative groups in terms of age and gender. Heart rate was higher in FQRS positive group. C-reactive protein (7.25 ±â€¯6.65 mg/dl vs. 4.80 ±â€¯4.48 mg/dl; p = .02) levels were also significantly higher in the FQRS positive group. In patients with SARS-COV-2, intensive care unit requirement increased with increasing levels of troponin (p < .000). A positive correlation was detected between serum CRP levels and FQRS (r = 0.204, p = .024). CONCLUSIONS: The frequency of FQRS is high in patients with SARS - COV - 2. Serum CRP levels increase with increasing frequency of FQRS in patients with SARS - COV - 2 indicating that patients with FQRS are exposed to more inflammation. Presence of FQRS in SARS - COV - 2 patients may be useful in predicting cardiovascular outcomes.